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Tuesday, May 5, 2020 | History

3 edition of New findings on HSV-induced retinitis in the von Szily model found in the catalog.

New findings on HSV-induced retinitis in the von Szily model

Manfred Zierhut

New findings on HSV-induced retinitis in the von Szily model

by Manfred Zierhut

  • 198 Want to read
  • 33 Currently reading

Published by Butterworth-Heinemann in Boston .
Written in English

    Subjects:
  • Herpes simplex.,
  • Retina -- Infections.,
  • Retinitis -- etiology.,
  • Retinitis -- immunology.,
  • Herpes Simplex -- complications.,
  • Simplexvirus -- immunology.,
  • Disease Models, Animal.

  • Edition Notes

    Includes bibliographical references (p. 84-95).

    StatementManfred Zierhut.
    Classifications
    LC ClassificationsRE901.H4 Z54 1994
    The Physical Object
    Pagination95 p. :
    Number of Pages95
    ID Numbers
    Open LibraryOL830362M
    ISBN 100750695889, 9070430061
    LC Control Number95104225
    OCLC/WorldCa30961716

    Group C (38 eyes of 25 patients) comprised HIV patients with no history of CMV retinitis but a history of CD4 count less than at some point lasting for at least 6 months. RESULTS: The average RNFL thicknesses in groups A, B, and C were +/- microm, +/- microm, and +/- microm, respectively. RESULTS: Each patient had uveitis with exudative retinal detachment, periphlebitis, and focal retinitis. Laboratory testing (fluorescent treponemal antibody absorption) revealed positive serology for active syphilis in all cases. Human immunodeficiency virus antibody testing was negative in all patients.

    Seven of 15 DBA/2 mice had clinical evidence of retinitis in the uninoculated eye by day 10 post-inoculation (p.i.). At this time, the average titer of virus in the uninoculated eyes was log10 PFU/ml. Animals of this strain also had significantly impaired HSV-1 . Retinitis Subject Areas on Research.

    Full text of "The principles and practice of perimetry" See other formats. Herpes simplex virus types 1 and 2, varicella zoster virus, cytomegalovirus and Epstein-Barr virus are known to cause retinitis. The prognosis of herpetic retinitis remains poor because it is associated with a high incidence of complications, both during and after the acute disease phase.


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New findings on HSV-induced retinitis in the von Szily model by Manfred Zierhut Download PDF EPUB FB2

New Findings on Hsv-Induced Retinitis in the Von Szily Model 1st Edition by Manfred Zierhut (Author)Author: Manfred Zierhut. This text contains the recent detailed results of the von Szily model, which is one of the few classical animal models in ophthalmology.

The book contains a complete listing of the literature existing about this subject, a historical survey and an overview of the immunology of the HSV infection.

Author(s): Zierhut,Manfred Title(s): New findings on HSV-induced retinitis in the von Szily model/ Manfred Zierhut.

Country of Publication: United States Publisher: Boston: Buren, Netherlands: Butterworth-Heinemann ; AEolus Press, c Retinitis pigmentosa: visual function and management Herse extinguish peripheral vision, while the central edge slowly constricts towards fixa-tion.5 Sleep disturbances occur in people with RP.

These people report lower sleep quality, shorter sleep duration, higher day-time dysfunction and a higher use of sleep-ing medications. The cause may be due toCited by: Herpes simplex virus (HSV) is the leading cause of infectious blindness in developed nations.

1 It is also known to infect a variety of cell types and cause numerous ocular diseases including blepharitis, stromal keratitis, chorioretinitis, and retinitis, among others. 2,3 Each year there areprimary cases of HSV-2 infection in the US and at least 22% of the population has a latent infection.

4,5 It has Cited by: Abstract In recent years, numerous reports have tied cytomegalovirus retinitis (CMVR) with multiple systemic conditions in the absence of human immunodeficiency virus (HIV) or acquired immunodefici Cited by: 4.

Retinitis pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies characterized by abnormalities of photoreceptors and retinal pigment epithelium that lead to progressive retinal degeneration, atrophy and ultimate visual loss. RP affects 1 in to people worldwide [1, 2].

Classification of retinitis pigmentosa reveals two main groups: “typical” or “non-syndromic” RP in which disease manifestations Cited by: The effects of relative hyperoxia on the retinal microcirculation in retinitis pigmentosa as well as intraocular inflammation may account for such changes.

Laser photocoagulation appears effective in preventing vitreous hemorrhage in these patients, but systemic administration of corticosteroids did not cause the new vessels to by: Note the white-yellow patches of necrotizing retinitis and considerable vitreous haze secondary to vitritis.

Figure 3 Coalescing of multiple areas of viral retinitis into ° of retinal necrosis. In addition to retinitis, vasculitis typically affecting the retinal arterioles occurs, although periphlebitis may also be observed.

Animal research has provided new realizations about the ultrastructure and physiological mechanisms of retinal photoreceptors, and better understanding of abnormal changes.

The possible pathogenesis of the human disease, based on research findings, is onsidered. RP is diagnosed in part through an examination of the retina. An eye care professional will use an ophthalmoscope, a tool that allows for a wider, clear view of the retina. This typically reveals abnormal, dark pigment deposits that streak the retina.

These pigment deposits are in part why the disorder was named retinitis pigmentosa. Retinitis pigmentosa (RP) is a leading cause of blindness and visual disability in younger people. Optometrists have a major role in detecting RP and in reducing the visual disability associated with by:   Viral retinitis is a rare disease that implies involvement of Herpesviridae, a family of double‐stranded DNA viruses characterised by latency within the host's cells after primary ive viruses include herpes simplex virus (HSV), varicella zoster virus (VZV)/herpes zoster virus (HZV), cytomegalovirus (CMV), and possibly Epstein‐Barr virus (EBV).Author: Xia Ni Wu, Sue Lightman, Oren Tomkins‐Netzer.

Kaposi Sarcoma: Kaposi sarcoma (KS) is a highly vascular tumor that appears as multiple purple-to-red nodules on the skin and mucous membranes.

In approximately 20% of individuals with HIV-associated KS, the tumor involves the eyelids, conjunctiva, and, in rare cases, the orbit.()The appearance of KS on the eyelids is similar to that of KS lesions elsewhere on the skin. The term retinitis pigmentosa (RP) refers to a group of hereditary diseases, all of which eventually result in severe vision loss.

Some of the diseases in the RP family are Usher syndrome, Lebers congenital amaurosis, rod-cone disease, Bardet-Biedl syndrome, and Refsum disease. Approximatelypeople in the U.S. have RP. Mass. Eye and Ear and the Harvard Medical School Department of Ophthalmology are proud to be leading this important clinical trial.

We look forward to reporting on safety and efficacy studies in the months and years to come. ReNeuron announces first patient treated in US Phase I/II clinical trial inblindness-causing disease, retinitis pigmentosa Marks initiation of ReNeuron’s clinical.

Retinitis pigmentosa is an inherited disorder, and therefore not caused by injury, infection or any other external or environmental factors.

People suffering from RP are born with the disorder already programmed into their cells. Doctors can see the first signs of retinitis pigmentosa in affected children as early as age Characteristic findings in the fundus with RP are bone–spicule deposits in the mid‐periphery or far periphery of the retina, waxy pallor optic disc and attenuation of retinal vessels.

The oxygen metabolic changes in the retina of a patient with RP are still by:   A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa. Vision Res. ; – Auricchio A, Kobinger G, Anand V, Hildinger M, O'Connor E, Maguire AM, et al. Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model.

Hum Mol by: Progressive outer retinal necrosis (PORN) is a herpetic retinitis that occurs in patients with AIDS and CD4+ cell counts less than cells/ µl. PORN begins as a smooth, granular, multifocal retinal opacification. Progression is much faster than with CMV retinitis, and there is typically little or no intraocular inflammation.

Progressive outer retinal necrosis (PORN) syndrome is a form of the Varicella zoster virus (VZV) chorioretinitis found almost exclusively in people with the acquired immunodeficiency syndrome (AIDS).

This destructive infection has an extremely rapid course that may lead to no light perception in affected eyes within days or by:   The association of NPHP and retinitis pigmentosa (RP) is known as Senior-Loken syndrome (SLS).

The RP is associated with 10% of cases of NPHP types 1, 3 and 4, and all cases of NPHP type 5, but never in NPHP type 2, the infantile form of by:   What is cytomegalovirus retinitis? Cytomegalovirus retinitis (CMV retinitis) is a serious viral eye infection of the retina.

The retina is the light-sensing nerve layer that lines the back of the eye. It is most often found in people with weakened immune systems.

What are symptoms of CMV retinitis?